panadol

Paracetamol

Perhaps the most familiar medicinal substance to all of us after aspirin.

It is a medicine that exists in every home and is used by young and old.

But how much do we know about its action and its correct use?

Paracetamol, also known as acetaminophen, is a mild inhibitor of prostaglandin synthesis and as such has an antipyretic, analgesic and mild anti-inflammatory effect.

It exerts its action mainly by acting centrally (cerebral) since it activates the descending analgesic pathways of the brain to the spinal cord (these pathways block the pain transmission signal to the spinal cord).

Where does the circuit of descending analgesia begin?
Descending analgesic pathway from the midbrain through the brainstem to the spinal cord. Neurons that secrete enkephalin inhibit the transmission of incoming pain fibers to the spinal cord.

It also has an effect on neuropathic pain.

PARACETAMOL DOSAGE

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