SAMe is a food supplement that contains S-Adenosyl-Methionine, vitamins B1, B6, B12 and Folic Acid.

Vitamins B1, B6 and B12 contribute to the normal function of metabolic processes designed to produce energy and folic acid contributes to the normal metabolism of homocysteine.

Notification number of the National Organization for Medicines (EOF):  100558 / 7-11-2017

The notification number in the National Organization for Medicines (EOF) does not serve as an authorization for marketing by the EOF.

Other Ingredients: microcrystalline cellulose, silica (Syloid FP-244), magnesium stearate, hypromellose, Gellan gum, titanium dioxide

PRECAUTIONS:

Do not take the product in the following cases:

(1) Hypersensitivity to any of its components.

(2) If you have a bipolar disorder.

(3) If you are taking antidepressants, consult your doctor before taking this medicine

WARNINGS:

• Do not to exceed the stated recommended daily allowance

• Nutritional Supplements do not replace a healthy diet

• Keep out of the reach of children.

• This product is not intended for prevention, treatment or cure of the human disease.

• Consult your doctor if you are pregnant of breastfeeding, if you are under pharmaceutical treatment or face health problems.

The benefits of SAMe for human health

SAMe (S-adenosyl-L-methionine) is an amino acid derivative naturally synthesized by the body to help produce and regulate hormones. It can also maintain the health of cell membranes. Its levels tend to decrease over time. It can be found in high concentrations on the liver and the brain, making it the basic source of methyl for the synthesis of hormones, nucleic acids, proteins, phospholipids and neurotransmitters (such as dopamine and serotonin). 

SAMe performs many biochemical functions within the body 

It is involved in multiple cellular reactions, but the three most important are:

1. Methylation: contributes to activating molecules.
2. Polyamines synthesis: cell growth, gene expression, neuronal rejuvenation, etc.
3. Synthesis of cysteine, glutathione and other sulphurous compounds. 

Its adequacy facilitates the utilization of glutathione and contributes to the generation and homeostasis of acetylcholine, an important neurotransmitter. Acetylcholine in turn helps mental function by preventing aging and degeneration of neurons.
In addition, it contributes to the synthesis of phosphatidylcholine, which has the property of maintaining the moisture within the cell membranes. It is a basic nutrient for the liver, which is essential for its smooth functioning, because it regulates the growth, death and differentiation of hepatocytes.

Doctor's Formulas SAMe is a nutritional supplement containing:

• S-Adenosyl Methionine
• Vitamins: B1, B6, B12 and Folic Acid

Vitamins B1, B6 and B12 contribute to the normal functioning of metabolic processes designed to produce energy and folic acid contributes to the normal metabolism of homocysteine.

✔Supplementation with SAMe helps to normalize mood and stimulates the hepatic levels of the vital antioxidant of glutathione, the most important natural antioxidant of the liver. In fact, studies have shown that maintaining SAMe levels in the body, protects and regenerates the liver. 

Precautions

Consult your doctor if you have a bipolar disorder

References

1. Drug Dev Res. 2016 Nov;77(7):346-356. doi: 10.1002/ddr.21345. Epub 2016 Sep 4. S-Adenosyl Methionine in the Therapy of Depression and Other Psychiatric Disorders. Karas Kuželički N1.

2. Cochrane Database Syst Rev. 2016 Oct 10;10:CD011286. S-adenosyl methionine (SAMe) for depression in adults. Galizia I1, Oldani L, Macritchie K, Amari E, Dougall D, Jones TN, Lam RW, Massei GJ, Yatham LN, Young AH.

3. World J Gastroenterol. 2016 Apr 14;22(14):3746-57. doi: 10.3748/wjg.v22.i14.3746. S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells. Lozano-Sepulveda SA1, Bautista-Osorio E1, Merino-Mascorro JA1, Varela-Rey M1, Muñoz-Espinosa LE1, Cordero-Perez P1, Martinez-Chantar ML1, Rivas-Estilla AM1.

4. J Clin Psychiatry. 2017 Jun;78(6):e656-e667. doi: 10.4088/JCP.16r11113. S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research. Sharma A1,2, Gerbarg P3, Bottiglieri T4, Massoumi L5, Carpenter LL6, Lavretsky H7, Muskin PR8, Brown RP8, Mischoulon D9; as Work Group of the American Psychiatric Association Council on Research.

5. Georgian Med News. 2017 Dec;(273):31-36. CLINICAL EFFICACY OF S-ADENOSYLMETHIONINE IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS AND CHRONIC KIDNEY DISEASE I-II STAGE. Antoniv A1, Antofiychuk N1, Danylyshina T1, Trefanenko I1, Shuper V1.

6. A double-blind, randomized, placebo-controlled clinical trial of S-adenosyl-L-methionine (SAMe) versus escitalopram in major depressive disorder. Mischoulon D, Price LH, Carpenter LL, Tyrka AR, Papakostas GI, Baer L, Dording CM, Clain AJ, Durham K, Walker R, Ludington E, Fava M. J Clin Psychiatry. 2014 Apr;75(4):370-6. doi: 10.4088/JCP.13m08591.

7. Oral SAMe in persistent treatment-refractory bipolar depression: a double-blind, randomized clinical trial. Murphy BL, Babb SM, Ravichandran C, Cohen BM. J Clin Psychopharmacol. 2014 Jun;34(3):413-6. doi: 10.1097/JCP.0000000000000064. No abstract available. PMID: 24699040

8. https://www.mayoclinic.org/drugs-supplements-same/art-20364924

9. https://nccih.nih.gov/health/supplements/SAMe